Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.63 |
| ▸ | RAF1 | P04049 | 8/20 | 0.62 |
| ▸ | BRAF | P15056 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.62 |
| ▸ | RET | P07949 | 3/20 | 0.62 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | BCR | P11274 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.62 |
| ▸ | FLT1 | P17948 | 2/20 | 0.62 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.62 |
| ▸ | TTK | P33981 | 2/20 | 0.62 |
| ▸ | FLT4 | P35916 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.62 |
| ▸ | CLK1 | P49759 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1658928 | 0.91 | RAF1 (0.69) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL1660279 | 0.91 | RAF1 (0.66) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL14911164 | 0.91 | ABL1 (0.73) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL1660353 | 0.91 | RAF1 (0.63) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL19888733 | 0.90 | ABL1 (0.65) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL10105554 | 0.89 | ABL1 (0.67) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL1660178 | 0.89 | RAF1 (0.68) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL1660265 | 0.88 | ABL1 (0.57) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL1659070 | 0.88 | MAPK14 (0.53) | ABL1RAF1BRAFKDRMAPK14 | |
| SCHEMBL19888749 | 0.88 | ABL1 (0.67) | ABL1RAF1BRAFKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |