Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29674805 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL27415737 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| Bromide SCHEMBL11820178 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| Methane SCHEMBL27506999 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| Nitric Acid SCHEMBL6691619 | 0.95 | ALDH1A1 (0.56) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL27680732 | 0.92 | ALDH1A1 (0.53) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL9284399 | 0.91 | LMNA (0.68) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL3292426 | 0.87 | ALDH1A1 (0.63) | ALDH1A1TDP1LMNACYP1A2CYP3A4 | |
| Ethyl Acetate SCHEMBL29093232 | 0.82 | ALDH1A1 (0.42) | ALDH1A1TDP1LMNAKDM4EMAPKAPK2 | |
| SCHEMBL5802254 | 0.81 | ALDH1A1 (0.46) | ALDH1A1LMNAPOLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 347 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363424-B1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | GENENTECH INC (US) | 2026-04-15 | — | — | EP | claimed |
| US-12429483-B2 | System and method for determining onset and disease progression | RESPIRATION SCAN LTD (IL) | 2025-09-30 | — | — | US | claimed |
| US-11999749-B2 | Synthesis of a bis-mesylate salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide and intermediates thereto | GENENTECH, INC. (US) | 2024-06-04 | — | — | US | claimed |
| EP-4363424-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | Genentech, Inc. (US) | 2024-05-08 | — | — | EP | claimed |
| CN-117580840-A | Synthesis of bis-mesylate salt of 4-amino-N- (1- ((3-chloro-2-fluorophenyl) amino) -6-methylisoquinolin-5-yl) thieno [3,2-D ] pyrimidine-7-carboxamide and intermediates thereof | 基因泰克公司 | 2024-02-20 | — | — | CN | claimed |
| US-20230028651-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1-((3-CHLORO-2-FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | GENENTECH, INC. (US) | 2023-01-26 | — | — | US | claimed |
| WO-2023278981-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | GENENTECH, INC. (US) | 2023-01-05 | — | — | WO | claimed |
| CN-107304080-B | Corrosion-inhibition, scale-inhibition and sterilization composition and application thereof | 中国石油化工股份有限公司 | 2020-05-12 | — | — | CN | claimed |
| CN-107304076-B | Corrosion-inhibition, scale-inhibition and sterilization composition and application thereof | 中国石油化工股份有限公司 | 2020-05-12 | — | — | CN | claimed |
| CN-107304082-B | Corrosion-inhibition, scale-inhibition and sterilization composition and application thereof | 中国石油化工股份有限公司 | 2020-05-12 | — | — | CN | claimed |
| US-20080051519-A1 | Polymers functionalized with nitro compounds | BRIDGESTONE CORPORATION (JP) | 2008-02-28 | — | — | US | claimed |
| US-6541487-B1 | Administering 5-bromoquinoline, 5-nitroisoquinoline, 8-nitroisoquinoline, 3,4-dihydro-6-hydroxy-2(1H)-quinolone or 1-methylisoquinoline to relax corpus cavernosa smooth-muscle tissue in males or females | R.T. ALAMO VENTURES I, LLC | 2003-04-01 | — | — | US | claimed |
| WO-2002019997-A1 | PDE III INHIBITORS FOR TREATING SEXUAL DYSFUNCTION | CUTLER NEAL R (US) | 2002-03-14 | — | — | WO | claimed |
| EP-1037873-B1 | METHOD FOR PRODUCING ORGANIC HYDROXYLAMINES | CONSORTIUM ELEKTROCHEM IND (DE) | 2001-08-22 | — | — | EP | claimed |
| US-6211410-B1 | PARTIALLY HYDROGENATING ORGANIC NITRO COMPOUND IN PRESENCE OF ORGANIC BASE OR AMMONIA, TRIVALENT PHOSPHORUS COMPOUND AND HYDROGENATION CATALYST | Consortium für elektrochemische Industrie GmbH (DE) | 2001-04-03 | — | — | US | claimed |
| EP-1037873-A1 | METHOD FOR PRODUCING ORGANIC HYDROXYLAMINES | Consortium für elektrochemische Industrie GmbH (DE) | 2000-09-27 | — | — | EP | claimed |
| US-5939568-A | Accelerated catalysis of olefinic epoxidations | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-08-17 | — | — | US | claimed |
| WO-1999028289-A1 | METHOD FOR PRODUCING ORGANIC HYDROXYLAMINES | Consortium für elektrochemische Industrie GmbH (DE) | 1999-06-10 | — | — | WO | claimed |
| WO-1998033786-A9 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | — | 1998-12-30 | — | — | WO | claimed |
| WO-1998033786-A1 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-08-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230028651-A1 | SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1-((3-CHLORO-2-FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO | BRAF, RAF1, KRAS | ALDH1A1 1412/4885TDP1 1464/4885LMNA 2680/4885 |
| US-11999749-B2 | Synthesis of a bis-mesylate salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide and intermediates thereto | BRAF, RAF1, KRAS | ALDH1A1 1775/4885TDP1 1307/4885LMNA 3867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.