Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10106742 | 0.89 | GPR119 (0.41) | GPR119LRRK2KMOLMNA | |
| SCHEMBL10106641 | 0.89 | GPR119 (0.36) | GPR119LRRK2 | |
| SCHEMBL10106470 | 0.89 | GPR119 (0.47) | GPR119KMOLMNA | |
| SCHEMBL10106633 | 0.84 | GPR119 (0.51) | GPR119 | |
| SCHEMBL10106722 | 0.83 | GPR119 (0.35) | GPR119KMO | |
| SCHEMBL10106676 | 0.81 | GPR119 (0.62) | GPR119 | |
| SCHEMBL10106740 | 0.80 | GPR119 (0.39) | GPR119 | |
| SCHEMBL10106294 | 0.77 | GPR119 (0.41) | GPR119LRRK2KMOLMNA | |
| SCHEMBL10106765 | 0.77 | GPR119 (0.40) | GPR119 | |
| SCHEMBL10106639 | 0.76 | GPR119 (0.51) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, BDKRB2, GLP1R | GPR119 1/4885LRRK2 446/4885KMO 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.