Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13150845 | 0.81 | IDO1 (0.48) | IDO1FEN1PDE4APDE4BPDE4C | |
| SCHEMBL11301840 | 0.81 | IDO1 (0.49) | IDO1FEN1PDE4APDE4BPDE4C | |
| SCHEMBL6930783 | 0.79 | PDE4A (0.49) | IDO1FEN1PDE4APDE4BPDE4C | |
| SCHEMBL1701244 | 0.78 | SMN1; SMN2 (0.52) | BRD4L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1462732 | 0.76 | KMT2A (0.50) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2611507 | 0.75 | KDM4E (0.64) | KDM4ERXFP1ALOX15TSHRTDP1 | |
| SCHEMBL30879806 | 0.75 | KDM4E (0.64) | KDM4ERXFP1ALOX15TSHRTDP1 | |
| SCHEMBL14472540 | 0.72 | TNKS (0.47) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9881569 | 0.71 | FEN1 (0.38) | IDO1FEN1PDE4APDE4BPDE4C | |
| SCHEMBL15228848 | 0.70 | KDM4E (0.38) | KDM4ERXFP1ALOX15TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157466-A1 | HETEROCYCLIC COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY | MERCK SHARP & DOHME CORP. | 2012-06-21 | — | — | US | disclosed |
| US-20120157466-A1 | HETEROCYCLIC COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY | MERCK SHARP & DOHME CORP. | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157466-A1 | HETEROCYCLIC COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY | CXCR3, ACKR3, CXCR1 | IDO1 187/4885FEN1 1920/4885PDE4A 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.