Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 6/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10107381 | 0.79 | IDO1 (0.45) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL1161498 | 0.78 | HDAC6 (0.64) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL29571733 | 0.78 | HDAC6 (0.64) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL6931699 | 0.77 | KDM4E (0.41) | PDE4APDE4BPDE4CPDE4DPDE10A | |
| SCHEMBL13150845 | 0.77 | IDO1 (0.48) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL1462732 | 0.72 | KMT2A (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6927584 | 0.71 | HDAC6 (0.43) | PDE10AKDM4EALOX15TSHRTDP1 | |
| SCHEMBL6929561 | 0.71 | HDAC6 (0.43) | PDE10AKDM4EALOX15TSHRTDP1 | |
| SCHEMBL12857748 | 0.69 | IDO1 (0.51) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL6512906 | 0.68 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |