Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010294 | 0.84 | NR1H4 (0.59) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL1009772 | 0.84 | NR1H4 (0.48) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL1010767 | 0.82 | ALDH1A1 (0.48) | MEN1KMT2ARAB9AKDM4E | |
| SCHEMBL27634916 | 0.82 | NR1H4 (0.46) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL27656110 | 0.82 | NR1H4 (0.47) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL12568856 | 0.81 | NR1H4 (0.49) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL1650967 | 0.80 | PTGDR2 (0.71) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL1010687 | 0.80 | ROCK2 (0.46) | PTGDR2NPC1RAB9A | |
| SCHEMBL1007096 | 0.79 | PTGDR2 (0.61) | NR1H4PTGDR2TBXA2RPTGDRMEN1 | |
| SCHEMBL1010965 | 0.78 | NR1H4 (0.55) | NR1H4PTGDR2MEN1KMT2ADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |