Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.61 |
| ▸ | CTSB | P07858 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | IRS1 | P35568 | 1/20 | 0.59 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL287025 | 0.89 | AKT1 (1.00) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL282800 | 0.87 | AKT1 (0.82) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL282833 | 0.85 | AKT1 (0.78) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL11891683 | 0.84 | AKT1 (0.77) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL5402056 | 0.84 | MEN1 (1.00) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL10555986 | 0.83 | RECQL (0.68) | AKT1ALDH1A1PKMCA1CA2 | |
| SCHEMBL282264 | 0.82 | AKT1 (0.74) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL5396386 | 0.82 | AKT1 (0.64) | AKT1MEN1KMT2AALDH1A1GAA | |
| Butadiazamide SCHEMBL2109869 | 0.82 | ALDH1A1 (0.69) | AKT1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10108461 | 0.82 | AKT1 (0.78) | AKT1ALDH1A1PKMHSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011032169-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |