Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | GAB1 | Q13480 | 3/20 | 0.58 |
| ▸ | IRS1 | P35568 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA3 | P07451 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555986 | 0.88 | RECQL (0.68) | AKT1ALDH1A1PKMGAB1IRS1 | |
| Sulfaethidole SCHEMBL152872 | 0.88 | AKT1 (1.00) | AKT1ALDH1A1PKMLMNAATM | |
| Butadiazamide SCHEMBL2109869 | 0.87 | ALDH1A1 (0.69) | AKT1ALDH1A1PKMLMNAGAB1 | |
| Sulfaethidole SCHEMBL10510090 | 0.86 | AKT1 (0.97) | AKT1ALDH1A1PKMLMNAATM | |
| Sulfaethidole SCHEMBL1651230 | 0.85 | AKT1 (0.95) | AKT1ALDH1A1PKMLMNAATM | |
| SCHEMBL11893089 | 0.85 | AKT1 (0.79) | AKT1ALDH1A1PKMLMNAATM | |
| SCHEMBL12829989 | 0.85 | AKT1 (0.88) | AKT1ALDH1A1PKMGAB1IRS1 | |
| SCHEMBL283033 | 0.82 | AKT1 (0.75) | AKT1ALDH1A1LMNAATMCA12 | |
| SCHEMBL10108459 | 0.82 | AKT1 (0.80) | AKT1ALDH1A1PKMGAB1IRS1 | |
| SCHEMBL11891684 | 0.82 | ALDH1A1 (0.77) | AKT1ALDH1A1LMNAATMCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011032169-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |