Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10108884 | 0.88 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3CACNA1B | |
| SCHEMBL13676877 | 0.80 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3TACR1ACHE | |
| SCHEMBL13676839 | 0.77 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL13676841 | 0.77 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3CACNA1BACHE | |
| SCHEMBL989955 | 0.76 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3CACNA1BTACR1 | |
| SCHEMBL10108805 | 0.76 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3NPY2RACHE | |
| SCHEMBL990020 | 0.76 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3CACNA1B | |
| SCHEMBL13676867 | 0.75 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL10108872 | 0.75 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL312487 | 0.74 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093285-B2 | Aminopiperidinyl derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090247568-A1 | AMINOPIPERIDINYL DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247568-A1 | AMINOPIPERIDINYL DERIVATIVES AND USES THEREOF | MAOB, ADORA2B, HTR1B | SLC6A2 8/4885SLC6A4 33/4885SLC6A3 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.