Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.61 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990020 | 0.85 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3CACNA1BOPRM1 | |
| SCHEMBL312487 | 0.76 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10108883 | 0.76 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3CACNA1BTACR1 | |
| SCHEMBL18475969 | 0.76 | NOS2 (0.47) | SLC6A2SLC6A4SLC6A3CACNA1BOPRM1 | |
| SCHEMBL16757238 | 0.76 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL22797780 | 0.75 | NOS2 (0.46) | SLC6A2SLC6A4SLC6A3CACNA1BOPRM1 | |
| SCHEMBL11692158 | 0.74 | OPRM1 (0.51) | SLC6A2SLC6A4SLC6A3OPRM1OPRK1 | |
| SCHEMBL4309799 | 0.74 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3CACNA1BGBA1 | |
| SCHEMBL28263500 | 0.74 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3OPRM1OPRK1 | |
| SCHEMBL12232428 | 0.74 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3CACNA1BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776046-A1 | COMPOSITIONS, DOSAGE FORMS, AND COADMINISTRATION OF AN OPIOID AGONIST COMPOUND AND AN ANALGESIC COMPOUND | Nektar Therapeutics (US) | 2014-09-17 | — | — | EP | disclosed |
| CN-103906522-A | Compositions, dosage forms, and coadministration of opioid agonist compound and analgesic compound | NEKTAR THERAPEUTICS | 2014-07-02 | — | — | CN | disclosed |
| WO-2013070617-A1 | COMPOSITIONS, DOSAGE FORMS, AND COADMINISTRATION OF AN OPIOID AGONIST COMPOUND AND AN ANALGESIC COMPOUND | NEKTAR THERAPEUTICS (US) | 2013-05-16 | — | — | WO | disclosed |
| EP-2456469-A1 | OLIGOMER-OPIOID AGONIST CONJUGATES | Nektar Therapeutics (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011543-A1 | OLIGOMER-OPIOID AGONIST CONJUGATES | NEKTAR THERAPEUTICS (US) | 2011-01-27 | — | — | WO | disclosed |