SCHEMBL1011084

SCHEMBL1011084

CC(F)(F)C(=O)CC#N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1012319 0.87
SCHEMBL1013569 0.83 MCL1 (0.38)
SCHEMBL23982819 0.83 MCL1 (0.38)
SCHEMBL24410357 0.83 MCL1 (0.38)
SCHEMBL3391018 0.83 MCL1 (0.38)
SCHEMBL573401 0.81
SCHEMBL133731 0.81
SCHEMBL5463212 0.79 MCL1 (0.42)
SCHEMBL1583542 0.78 MCL1 (0.40)
SCHEMBL1013199 0.78 MCL1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12611404-B2 Aza-aryl 1H-pyrazol-1-yl benzene sulfonamides CHEMOCENTRYX, INC. (US) 2026-04-28 US disclosed
US-20230265075-A1 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS AJAX THERAPEUTICS, INC. 2023-08-24 US disclosed
US-11691963-B2 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors AJAX THERAPEUTICS, INC. (US) 2023-07-04 US disclosed
US-20220047575-A1 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES CHEMOCENTRYX, INC. 2022-02-17 US disclosed
EP-3738958-A1 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR(9) ANTAGONISTS ChemoCentryx, Inc. (US) 2020-11-18 EP disclosed
US-20200197386-A1 Aza-Aryl 1H-Pyrazol-yl Benzene Sulfonamides CHEMOCENTRYX INC (US) 2020-06-25 US disclosed
US-20200197386-A1 Aza-Aryl 1H-Pyrazol-yl Benzene Sulfonamides CHEMOCENTRYX INC (US) 2020-06-25 US disclosed
EP-3263564-B1 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR(9) ANTAGONISTS CHEMOCENTRYX INC (US) 2020-06-10 EP disclosed
US-10596163-B2 Aza-aryl 1H-pyrazol-1-yl benzene sulfonamides CHEMOCENTRYX, INC. (US) 2020-03-24 US disclosed
US-10596163-B2 Aza-aryl 1H-pyrazol-1-yl benzene sulfonamides CHEMOCENTRYX, INC. (US) 2020-03-24 US disclosed
US-8618289-B2 RAF kinase modulator compounds and methods of use thereof AMBIT BIOSCIENCES CORPORATION (US) 2013-12-31 US disclosed
WO-2013130811-A1 PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS CHEMOCENTRYX, INC. (US) 2013-09-06 WO disclosed
WO-2013130811-A1 PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS CHEMOCENTRYX, INC. (US) 2013-09-06 WO disclosed
US-20130225580-A1 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES CHEMOCENTRYX, INC. (US) 2013-08-29 US disclosed
US-20130225580-A1 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES CHEMOCENTRYX, INC. (US) 2013-08-29 US disclosed
US-20130225580-A1 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES CHEMOCENTRYX, INC. (US) 2013-08-29 US disclosed
EP-2274297-B1 PYRROLIDINONE GLUCOKINASE ACTIVATORS HOFFMANN LA ROCHE (CH) 2012-05-09 EP disclosed
US-20110118245-A1 RAF KINASE MODULATOR COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORP. 2011-05-19 US disclosed
EP-2268623-A1 QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF Ambit Biosciences Corporation (US) 2011-01-05 EP disclosed
WO-2009117080-A1 QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATON (US) 2009-09-24 WO disclosed