Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011084 | 0.83 | — | — | |
| SCHEMBL1013569 | 0.82 | MCL1 (0.38) | MCL1CYP1A2CYP3A4CYP2C19PDK1 | |
| SCHEMBL1012319 | 0.81 | — | — | |
| SCHEMBL24410357 | 0.77 | MCL1 (0.38) | MCL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23982819 | 0.77 | MCL1 (0.38) | MCL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1014847 | 0.76 | MCL1 (0.40) | MCL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL133731 | 0.75 | — | — | |
| SCHEMBL573401 | 0.75 | — | — | |
| SCHEMBL5463212 | 0.73 | MCL1 (0.42) | MCL1CYP1A2CYP2C19 | |
| SCHEMBL1583542 | 0.73 | MCL1 (0.40) | MCL1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |