Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.38 |
| ▸ | AXL | P30530 | 3/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10112447 | 0.86 | TNF (0.47) | TNFALPLFGFR1FGFR2FGFR3 | |
| SCHEMBL10112432 | 0.80 | TNF (0.43) | TNFFGFR1FGFR2FGFR3AXL | |
| SCHEMBL10112433 | 0.79 | AXL (0.43) | TNFFGFR1FGFR2FGFR3AXL | |
| SCHEMBL18183699 | 0.72 | AXL (0.50) | AXLMERTKCYP2C9PIM1CREBBP | |
| SCHEMBL10112442 | 0.72 | TNF (0.47) | TNFFGFR1FGFR2FGFR3AXL | |
| SCHEMBL10112438 | 0.72 | TNF (0.48) | TNFFGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL20064797 | 0.66 | NTRK1 (0.40) | FGFR1FGFR3AXLMERTKPDGFRB | |
| SCHEMBL20064815 | 0.65 | STING1 (0.39) | FGFR1FGFR3AXLMERTKPDGFRB | |
| SCHEMBL10112367 | 0.65 | FYN (0.44) | TNFFGFR1FGFR2FGFR3AXL | |
| Lithium Ion SCHEMBL30477028 | 0.64 | FYN (0.35) | FGFR1FGFR3AXLMERTKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541572-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541572-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, ADAMTS1, ADAMTS7 | TNF 1/4885ALPL 189/4885FGFR1 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.