Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.64 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.51 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669645 | 0.90 | DGAT1 (0.54) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL1444238 | 0.84 | DGAT1 (0.68) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL670183 | 0.78 | MAPT (0.48) | DGAT1SOAT1CYP3A4MAPTPOLB | |
| SCHEMBL10113679 | 0.78 | DGAT1 (1.00) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113332 | 0.77 | DGAT1 (0.86) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL5453369 | 0.77 | L3MBTL1 (0.70) | MAPTPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL3542849 | 0.77 | MAPT (0.64) | MAPTKDM4EPOLBL3MBTL1MEN1 | |
| SCHEMBL3542851 | 0.77 | MAPT (0.64) | MAPTKDM4EPOLBL3MBTL1MEN1 | |
| SCHEMBL10112844 | 0.77 | DGAT1 (0.81) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113345 | 0.77 | DGAT1 (0.75) | DGAT1SOAT1CYP3A4SOAT2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |