Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14990215 | 0.93 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL15003808 | 0.93 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14990216 | 0.93 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL670111 | 0.93 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14990181 | 0.84 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14990180 | 0.84 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL10114227 | 0.84 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL10114216 | 0.84 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14999183 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14999180 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024437-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2012-02-23 | — | — | WO | disclosed |