Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14990215 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL14990216 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL15003808 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL10114213 | 0.93 | ALDH1A1 (0.66) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL14990180 | 0.92 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL10114227 | 0.92 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL14990181 | 0.92 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL10114216 | 0.92 | KMT2A (0.53) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL14999180 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 | |
| SCHEMBL14999183 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EKMT2ACYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073920-B2 | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor | PURDUE RESEARCH FOUNDATION (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | KRAS, QDPR, BTD | ALDH1A1 1798/4885KDM4E 3525/4885KMT2A 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.