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SCHEMBL10114923

SCHEMBL10114923

CC(C)S(=O)(=O)NC1CCC(C(=O)Nc2cccc(S(=O)(=O)NC3CCCCC3)c2)CC1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.56
▸ ALDH1A1 P00352 5/20 0.56
▸ KMT2A Q03164 1/20 0.56
▸ HTT P42858 2/20 0.55
▸ SMN1; SMN2 Q16637 2/20 0.55
▸ USP2 O75604 1/20 0.55
▸ GAA P10253 1/20 0.55
▸ HPGD P15428 1/20 0.55
▸ GRIA2 P42262 1/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.46
▸ BRD4 O60885 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ KIF18A Q8NI77 1/20 0.45
▸ POLB P06746 1/20 0.45
▸ TP53 P04637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14424382 1.00 LMNA (0.56) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL13204411 0.91 LMNA (0.56) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL10114929 0.91 LMNA (0.56) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL10114988 0.89 LMNA (0.59) LMNAALDH1A1HTTSMN1; SMN2USP2
SCHEMBL13204425 0.89 LMNA (0.59) LMNAALDH1A1HTTSMN1; SMN2USP2
SCHEMBL14424378 0.87 KMT2A (0.58) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL10114911 0.87 KMT2A (0.58) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL14424788 0.85 LMNA (0.56) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL10114544 0.85 LMNA (0.56) LMNAALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL13204423 0.85 RHOA (0.54) LMNAALDH1A1KMT2AHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R LMNA 1925/4885ALDH1A1 4558/4885KMT2A 2912/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R LMNA 2068/4885ALDH1A1 4599/4885KMT2A 2768/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R LMNA 1857/4885ALDH1A1 4517/4885KMT2A 2953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.