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SCHEMBL10116153

SCHEMBL10116153

Cc1cc(-c2ncco2)ccc1NC(=O)N1CCC(NS(=O)(=O)C(C)C)CC1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ GRIA2 P42262 5/20 0.39
▸ GSK3B P49841 2/20 0.39
▸ DYRK1A Q13627 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ THRB P10828 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ FAAH O00519 1/20 0.37
▸ EPHX2 P34913 1/20 0.37
▸ CCR8 P51685 3/20 0.37
▸ MAPK1 P28482 1/20 0.36
▸ LTA4H P09960 1/20 0.36
▸ POLB P06746 1/20 0.35
▸ KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10115817 0.88 RAB9A (0.39) RAB9ATHRBNPC1FAAHEPHX2
SCHEMBL10116160 0.87 GSK3B (0.36) GRIA2GSK3BDYRK1ARAB9ATHRB
SCHEMBL10116125 0.86 FAAH (0.47) GRIA2GSK3BDYRK1ARAB9ANPC1
SCHEMBL13204440 0.85 GRIA2 (0.42) GRIA2RAB9ANPC1FAAHEPHX2
SCHEMBL10114994 0.85 GRIA2 (0.42) GRIA2RAB9ANPC1FAAHEPHX2
SCHEMBL17090429 0.79 GRIA2 (0.41) GRIA2
SCHEMBL13564909 0.79 GRIA2 (0.41) GRIA2
SCHEMBL10116162 0.78 HDAC1 (0.52) GRIA2RAB9ATHRBNPC1EPHX2
SCHEMBL10116019 0.77 EPHX2 (0.46) RAB9ATHRBNPC1EPHX2CCR8
SCHEMBL10115832 0.77 FAAH (0.36) RAB9ATHRBNPC1FAAHEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R GRIA2 347/4885GSK3B 2267/4885DYRK1A 543/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R GRIA2 334/4885GSK3B 2333/4885DYRK1A 584/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R GRIA2 358/4885GSK3B 2284/4885DYRK1A 549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.