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Sugi Predict / Compounds / SCHEMBL10116675

SCHEMBL10116675

SCHEMBL10116675

CC(C)S(=O)(=O)Nc1ccc(C(=O)Nc2ccc(S(=O)(=O)NC3CCCCC3)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.58
▸ ALDH1A1 P00352 4/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ MEN1 O00255 2/20 0.57
▸ HPGD P15428 3/20 0.55
▸ GRM4 Q14833 1/20 0.55
▸ TP53 P04637 1/20 0.54
▸ KDM4E B2RXH2 1/20 0.53
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ TSHR P16473 1/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ POLB P06746 1/20 0.51
▸ GAA P10253 1/20 0.51
▸ STK25 O00506 1/20 0.51
▸ ALOX12 P18054 1/20 0.50
▸ NPSR1 Q6W5P4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10116673 0.89 LMNA (0.56) LMNAALDH1A1KMT2AMEN1HPGD
SCHEMBL10116668 0.86 NPC1 (0.56) LMNAALDH1A1KMT2AMEN1HPGD
SCHEMBL10116380 0.84 LMNA (0.58) LMNAALDH1A1KMT2AMEN1HPGD
SCHEMBL10116695 0.82 LMNA (0.69) LMNAALDH1A1KMT2AMEN1HPGD
SCHEMBL10116740 0.81 HDAC8 (0.64) LMNAALDH1A1TP53KDM4ESMN1; SMN2
SCHEMBL10116705 0.81 PTPN1 (0.52) LMNAKMT2AMEN1HPGDKDM4E
SCHEMBL10116638 0.81 KMT2A (0.60) LMNAALDH1A1KMT2AHPGDSMN1; SMN2
SCHEMBL14424378 0.79 KMT2A (0.58) LMNAALDH1A1KMT2AMEN1HPGD
SCHEMBL13565840 0.79 ALDH1A1 (0.58) LMNAALDH1A1KMT2AMEN1HPGD
SCHEMBL10114911 0.79 KMT2A (0.58) LMNAALDH1A1KMT2AMEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R LMNA 1925/4885ALDH1A1 4558/4885KMT2A 2912/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R LMNA 2068/4885ALDH1A1 4599/4885KMT2A 2768/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R LMNA 1857/4885ALDH1A1 4517/4885KMT2A 2953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.