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SCHEMBL10117596

SCHEMBL10117596

C1=Cc2c(oc3c(-c4ccc(C5(c6ccc(C7(c8ccccc8)c8ccccc8-c8ccccc87)cc6)c6ccccc6-c6ccccc65)cc4)cccc23)CC1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ OPRK1 P41145 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ ALOX5 P09917 1/20 0.30
▸ ESR1 P03372 1/20 0.30
▸ ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21784249 0.84 PRKDC (0.39) KDM4ELMNASMN1; SMN2ALOX5
SCHEMBL24135869 0.84 — —
SCHEMBL13052184 0.81 ALOX5 (0.45) ALOX5
SCHEMBL21936571 0.79 ALDH1A1 (0.33) KDM4EMEN1LMNAMAPTKMT2A
SCHEMBL16475422 0.78 — —
SCHEMBL440035 0.78 KDM4E (0.45) KDM4EMEN1LMNAMAPTOPRK1
SCHEMBL371292 0.77 ALOX5 (0.51) KDM4EMEN1LMNAMAPTOPRK1
SCHEMBL29572728 0.77 ALOX5 (0.51) KDM4EMEN1LMNAMAPTOPRK1
SCHEMBL438618 0.77 ALOX5 (0.51) KDM4EMEN1LMNAMAPTOPRK1
SCHEMBL437624 0.76 KDM4E (0.46) KDM4EMEN1LMNAMAPTOPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2428512-A2 Fluorene compound, light-emitting element, light-emitting device, electronic device and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-03-14 — — EP disclosed
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