Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010687 | 0.93 | ROCK2 (0.46) | SMN1; SMN2MGLLPTGDR2ROCK2POLB | |
| SCHEMBL1010059 | 0.84 | MEN1 (0.47) | KMT2AMEN1SMN1; SMN2L3MBTL1MGLL | |
| SCHEMBL1010767 | 0.82 | ALDH1A1 (0.48) | KMT2AMEN1 | |
| SCHEMBL1010810 | 0.82 | MEN1 (0.47) | KMT2AMEN1SMN1; SMN2L3MBTL1MGLL | |
| SCHEMBL15746542 | 0.77 | PTGDR2 (0.45) | KMT2AMEN1SMN1; SMN2L3MBTL1TBXA2R | |
| SCHEMBL5961340 | 0.77 | MEN1 (0.52) | KMT2AMEN1SMN1; SMN2L3MBTL1MGLL | |
| SCHEMBL1008677 | 0.77 | PTGDR2 (0.47) | TBXA2RPTGDRPTGDR2ROCK2POLB | |
| SCHEMBL27655918 | 0.76 | POLB (0.43) | KMT2APTGDR2ROCK2CYP2C19POLB | |
| SCHEMBL1010809 | 0.76 | MEN1 (0.48) | KMT2AMEN1SMN1; SMN2L3MBTL1MGLL | |
| SCHEMBL27634906 | 0.76 | POLB (0.45) | SMN1; SMN2MGLLPTGDR2ROCK2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |