Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11498271 | 0.81 | AKR1C3 (0.53) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL17421184 | 0.81 | KMT2A (0.56) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL10117848 | 0.80 | GSK3B (0.52) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL17077807 | 0.79 | MAPT (0.54) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL17077674 | 0.79 | MAPK13 (0.71) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL9478869 | 0.77 | MAPT (0.71) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL1930247 | 0.77 | MAPT (0.71) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL6834346 | 0.77 | AKR1C3 (0.49) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL6906973 | 0.77 | RAB9A (0.60) | MAPK13MAPK12MAPK11MAPK14AKR1C3 | |
| SCHEMBL20564586 | 0.76 | MAPT (0.60) | MAPK13MAPK12MAPK11MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087976-A2 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-06-28 | — | — | WO | disclosed |