Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.65 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107037 | 0.82 | KMT2A (0.60) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL2526234 | 0.80 | KMT2A (0.63) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL27536602 | 0.79 | KMT2A (0.52) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL155225 | 0.78 | KMT2A (1.00) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL27562774 | 0.78 | KMT2A (0.56) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL5747190 | 0.78 | KMT2A (0.56) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL11318423 | 0.78 | KMT2A (0.56) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL2480787 | 0.78 | KMT2A (0.61) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL11538261 | 0.78 | KMT2A (0.52) | KMT2APOLBMEN1AGTR1CES2 | |
| SCHEMBL17111051 | 0.77 | KMT2A (0.96) | KMT2APOLBMEN1AGTR1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021707-A2 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-16 | — | — | WO | disclosed |