Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 7/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.54 |
| ▸ | CCR2 | P41597 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392709 | 0.88 | P2RX3 (0.62) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL10146036 | 0.86 | RXFP1 (0.69) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL10120633 | 0.84 | CCR1 (0.65) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL10120637 | 0.83 | CCR1 (0.63) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL6782671 | 0.82 | CCR1 (1.00) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL2232358 | 0.80 | CCR1 (0.59) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL10120631 | 0.79 | CCR1 (0.58) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL12943326 | 0.77 | RXFP1 (0.55) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL10116902 | 0.77 | P2RX3 (0.66) | CCR1KDM4EHPGDP2RX3MEN1 | |
| SCHEMBL10116926 | 0.76 | KDM4E (0.69) | CCR1KDM4EHPGDP2RX3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497263-B2 | Pyrrolinone derivative and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2013-07-30 | — | — | US | disclosed |
| US-20120010199-A1 | NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KAI HIROYUKI (JP) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010199-A1 | NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | P2RX3, P2RX2, P2RX1 | CCR1 1184/4885KDM4E 3560/4885HPGD 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.