Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10120795 | 0.91 | TNK2 (0.33) | TMPRSS2TNK2 | |
| SCHEMBL18636433 | 0.91 | BACE1 (0.34) | TMPRSS2TNK2RIPK1 | |
| SCHEMBL20144181 | 0.91 | BACE1 (0.34) | TMPRSS2TNK2RIPK1 | |
| SCHEMBL12243225 | 0.88 | NPC1 (0.35) | TMPRSS2TNK2RIPK1 | |
| SCHEMBL13667660 | 0.85 | TMPRSS2 (0.41) | TMPRSS2RIPK1 | |
| SCHEMBL19504314 | 0.82 | TMPRSS2 (0.38) | TMPRSS2 | |
| SCHEMBL10153929 | 0.81 | TMPRSS2 (0.44) | TMPRSS2ACVRL1 | |
| SCHEMBL882530 | 0.81 | TMPRSS2 (0.41) | TMPRSS2ACVRL1 | |
| SCHEMBL18636432 | 0.81 | TMPRSS2 (0.36) | TMPRSS2TNK2RIPK1 | |
| SCHEMBL12835932 | 0.80 | BACE1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027752-A1 | METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120027752-A1 | METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS | PNP, RPIA, HPRT1 | TMPRSS2 433/4885TNK2 3193/4885RIPK1 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.