Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153929 | 0.90 | TMPRSS2 (0.44) | TMPRSS2PIK3CDACVRL1 | |
| SCHEMBL12454229 | 0.86 | POLRMT (0.38) | TMPRSS2PIK3CD | |
| SCHEMBL19504314 | 0.85 | TMPRSS2 (0.38) | TMPRSS2 | |
| SCHEMBL13667660 | 0.84 | TMPRSS2 (0.41) | TMPRSS2 | |
| SCHEMBL10082720 | 0.82 | BACE1 (0.34) | TMPRSS2PIK3CD | |
| SCHEMBL10120799 | 0.81 | TMPRSS2 (0.36) | TMPRSS2ACVRL1 | |
| SCHEMBL18697868 | 0.81 | RIPK1 (0.31) | — | |
| SCHEMBL13667663 | 0.80 | TMPRSS2 (0.51) | TMPRSS2PIK3CDACVRL1 | |
| SCHEMBL25610105 | 0.79 | TMPRSS2 (0.37) | TMPRSS2 | |
| Gs-441524 SCHEMBL24975226 | 0.79 | TMPRSS2 (0.60) | TMPRSS2ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087596-A1 | COMBINATIONS FOR TREATING HCV | GILEAD SCIENCES, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012039791-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |