Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 6/20 | 1.00 |
| ▸ | ENPP1 | P22413 | 4/20 | 1.00 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 1.00 |
| ▸ | P2RX3 | P56373 | 2/20 | 1.00 |
| ▸ | P2RX1 | P51575 | 1/20 | 1.00 |
| ▸ | P2RY6 | Q15077 | 1/20 | 1.00 |
| ▸ | P2RX4 | Q99571 | 1/20 | 1.00 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375601 | 1.00 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL29381860 | 1.00 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL375602 | 1.00 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL195864 | 0.99 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL195865 | 0.99 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL18089710 | 0.99 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL12216627 | 0.97 | P2RY1 (0.95) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL18089797 | 0.94 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL18089712 | 0.93 | P2RY1 (0.89) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL3490789 | 0.92 | P2RY1 (0.86) | P2RY1ENPP1P2RY11P2RX3P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9526739-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-12-27 | — | — | US | disclosed |
| US-9526739-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | GOOGLE LLC | 2016-06-16 | — | — | US | disclosed |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | GOOGLE LLC | 2016-06-16 | — | — | US | disclosed |
| US-9303053-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-04-05 | — | — | US | disclosed |
| US-9303053-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2015-02-05 | — | — | US | disclosed |
| US-8822434-B2 | Compositions and methods to treat cardiac diseases | THE UNIVERSITY OF CONNECTICUT (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822434-B2 | Compositions and methods to treat cardiac diseases | THE UNIVERSITY OF CONNECTICUT (US) | 2014-09-02 | — | — | US | disclosed |
| WO-2011103552-A9 | AMP DERIVATIVES FOR TREATING CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2012-04-26 | — | — | WO | disclosed |
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT | 2011-09-01 | — | — | US | disclosed |
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT | 2011-09-01 | — | — | US | disclosed |
| WO-2011103552-A2 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | P2RY1 4/4885ENPP1 61/4885P2RY11 13/4885 |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | P2RY1 4/4885ENPP1 61/4885P2RY11 13/4885 |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | P2RY1 4/4885ENPP1 61/4885P2RY11 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.