Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 6/20 | 1.00 |
| ▸ | ENPP1 | P22413 | 4/20 | 1.00 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 1.00 |
| ▸ | P2RX3 | P56373 | 2/20 | 1.00 |
| ▸ | P2RX1 | P51575 | 1/20 | 1.00 |
| ▸ | P2RY6 | Q15077 | 1/20 | 1.00 |
| ▸ | P2RX4 | Q99571 | 1/20 | 1.00 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381860 | 1.00 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL375601 | 1.00 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL10120953 | 1.00 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL18089710 | 0.99 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL195864 | 0.99 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL195865 | 0.99 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL12216627 | 0.97 | P2RY1 (0.95) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL18089797 | 0.94 | P2RY1 (1.00) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL18089712 | 0.93 | P2RY1 (0.89) | P2RY1ENPP1P2RY11P2RX3P2RX1 | |
| SCHEMBL8862410 | 0.92 | P2RY1 (0.86) | P2RY1ENPP1P2RY11P2RX3P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960131-B2 | Functional genomic pore assay for mixed cell populations | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-06-14 | — | — | US | claimed |
| US-7560243-B2 | White blood cell functional assay | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-07-14 | — | — | US | claimed |
| US-20090053204-A1 | Functional Genomic Pore Assay For Mixed Cell Populations | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-02-26 | — | — | US | claimed |
| WO-2005079250-A2 | PURINES ARE SELF-RENEWAL SIGNALS FOR NEURAL STEM CELLS, AND PURINE RECEPTOR ANTAGONISTS PROMOTE NEURONAL AND GLIAL DIFFERENTIATION THEREFROM | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-09-01 | — | — | WO | claimed |
| US-20050181503-A1 | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-18 | — | — | US | claimed |
| US-20050053612-A1 | Nucleotide regulation of immune responses | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-03-10 | — | — | US | claimed |
| US-20040253650-A1 | White blood cell functional assay | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-12-16 | — | — | US | claimed |
| US-20030059878-A1 | Novel purinoceptor and gene thereof | TANABE SEIYAKU CO., LTD (JP) | 2003-03-27 | — | — | US | claimed |
| CN-107029237-B | Application of thermogenesis enhancing compound in enhancing thermogenesis of noradrenaline compound induced brown fat cells | 康建胜 | 2021-06-25 | — | — | CN | disclosed |
| EP-2049127-B1 | N-METHANOCARBA DERIVATIVES TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2014170343-A1 | DEPOLARIZING AGENTS AND NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS FOR TREATING DOPAMINERGIC-RELATED DISORDERS | ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) | 2014-10-23 | — | — | WO | disclosed |
| US-8410078-B2 | Composition and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2410332-A1 | Method for identifying purinergic modulators of the olfactory system | The University Of Utah (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-1624753-B1 | PURINERGIC MODULATION OF SMELL | UNIV UTAH RES FOUND (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2005079250-A2 | PURINES ARE SELF-RENEWAL SIGNALS FOR NEURAL STEM CELLS, AND PURINE RECEPTOR ANTAGONISTS PROMOTE NEURONAL AND GLIAL DIFFERENTIATION THEREFROM | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050181503-A1 | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-18 | — | — | US | disclosed |
| US-20050053612-A1 | Nucleotide regulation of immune responses | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-03-10 | — | — | US | disclosed |
| US-20040253650-A1 | White blood cell functional assay | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-12-16 | — | — | US | disclosed |
| US-20030059878-A1 | Novel purinoceptor and gene thereof | TANABE SEIYAKU CO., LTD (JP) | 2003-03-27 | — | — | US | disclosed |
| WO-1999043326-A1 | USE OF A CARDIAC PURINOCEPTOR TO EFFECT CELLULAR GLUCOSE UPTAKE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050053612-A1 | Nucleotide regulation of immune responses | NT5C2, ENTPD5, ENTPD1 | P2RY1 7/4885ENPP1 44/4885P2RY11 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.