⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209495 | 0.73 | — | — | |
| SCHEMBL12772862 | 0.71 | SMN1; SMN2 (0.36) | — | |
| Hydrochloric Acid SCHEMBL28503994 | 0.71 | RAB9A (0.38) | — | |
| SCHEMBL12854185 | 0.69 | — | — | |
| SCHEMBL6125031 | 0.68 | — | — | |
| SCHEMBL4763102 | 0.68 | — | — | |
| SCHEMBL7051483 | 0.66 | — | — | |
| SCHEMBL26702 | 0.66 | — | — | |
| SCHEMBL6738669 | 0.65 | — | — | |
| SCHEMBL8325180 | 0.65 | RAB9A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708314-B2 | Heterocyclic amide compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-20170143718-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | BIOFOCUS DPI LTD. (GB) | 2017-05-25 | — | — | US | disclosed |
| EP-2701510-B1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | USHER III INITIATIVE INC (US) | 2017-02-15 | — | — | EP | disclosed |
| US-9549910-B2 | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome | USHER III INITIATIVE, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20160158172-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | USHER III INITIATIVE, INC. | 2016-06-09 | — | — | US | disclosed |
| US-20160108037-A1 | HETEROCYCLIC AMIDE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2016-04-21 | — | — | US | disclosed |
| US-20160108016-A1 | Novel Cannabinergic Compounds and Uses Thereof | NORTHEASTERN UNIVERSITY (US) | 2016-04-21 | — | — | US | disclosed |
| US-9260381-B2 | Pyrazolopyridazines and methods for treating retinal degenerative diseases and hearing loss associated with usher syndrome | USHER III INITIATIVE, INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150266812-A1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | USHER III INITIATIVE, INC. | 2015-09-24 | — | — | US | disclosed |
| US-9079909-B2 | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher Syndrome | USHER III INITIATIVE, INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-8236766-B2 | Uses of synthetic peptide amides | CARA THERAPEUTICS, INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-8119796-B2 | Biphenyl compounds useful as muscarinic receptor antagonists | THERAVANCE, INC. (US) | 2012-02-21 | — | — | US | disclosed |
| US-20120022045-A1 | BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS | VENKATRAMAN SHANKAR (US) | 2012-01-26 | — | — | US | disclosed |
| US-20110275621-A1 | HIV INTEGRASE INHIBITORS | SCHERING CORPORATION | 2011-11-10 | — | — | US | disclosed |
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110245296-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK CANADA INC. (CA) | 2011-10-06 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-20070276008-A1 | Pharmaceutical formulation comprising glycine as a stabilizer | EISAI COMPANY LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| US-7230014-B1 | Pharmaceutical formulation comprising glycine as a stabilizer | EISAI CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |
| US-20070060622-A1 | Compositions and methods using proton pump inhibitors | EISAI CO., LTD. (JP) | 2007-03-15 | — | — | US | disclosed |