Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | KIF5B | P33176 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 6/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012315 | 0.90 | EGFR (0.51) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL4386131 | 0.83 | EGFR (0.59) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL1012180 | 0.78 | KDR (0.73) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL14478889 | 0.77 | EGFR (0.58) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL4375169 | 0.76 | KDM1A (0.76) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL2473728 | 0.76 | KIT (0.61) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL18158551 | 0.74 | KDM1A (0.62) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL1015599 | 0.74 | TRPA1 (0.61) | EGFRKDRRETLCKKIF5B | |
| O-Tolylamine SCHEMBL27484550 | 0.74 | HPGD (0.50) | EGFRKDRRETLCKCSF1R | |
| SCHEMBL7209616 | 0.73 | KDR (1.00) | EGFRKDRRETLCKKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |