Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | PLK4 | O00444 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10122960 | 0.88 | AURKA (0.54) | AURKAAURKBIGF1RRETPLK4 | |
| SCHEMBL16660290 | 0.85 | DYRK1A (0.41) | IGF1RTYK2DYRK1AJAK1TGFBR1 | |
| SCHEMBL10122991 | 0.85 | AURKA (0.49) | AURKAAURKBIGF1RRETPLK4 | |
| SCHEMBL10123002 | 0.83 | AURKA (0.48) | AURKAAURKBIGF1RRETPLK4 | |
| SCHEMBL10123026 | 0.81 | AURKA (0.47) | AURKAAURKBIGF1RRETPLK4 | |
| SCHEMBL10123014 | 0.81 | AURKA (0.49) | AURKAAURKBIGF1RRETPLK4 | |
| SCHEMBL10122964 | 0.80 | AURKA (0.50) | AURKAAURKBRIPK1IGF1RAURKC | |
| SCHEMBL10122894 | 0.79 | AURKA (0.69) | AURKAAURKBRIPK1IGF1RAURKC | |
| SCHEMBL10122958 | 0.75 | AURKA (0.47) | AURKAAURKBIGF1RAURKCRET | |
| SCHEMBL10123046 | 0.74 | ALDH1A1 (0.49) | CYP1A2CYP3A4CYP2C9TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114870-B2 | Method of treating disease states using substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8114870-B2 | Method of treating disease states using substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-7563787-B2 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2009-07-21 | — | — | US | disclosed |
| US-7563787-B2 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2009-07-21 | — | — | US | disclosed |
| US-20070142368-A1 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. | 2007-06-21 | — | — | US | disclosed |
| US-20070142368-A1 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. | 2007-06-21 | — | — | US | disclosed |
| WO-2007041358-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142368-A1 | Substituted pyrazole compounds | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885RIPK1 728/4885 |
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | AURKC, AURKA, AURKB | AURKA 2/4885AURKB 3/4885RIPK1 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.