Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660271 | 0.85 | ALDH1A1 (0.46) | SMN1; SMN2TGFBR1LMNAKMT2AALDH1A1 | |
| SCHEMBL10122962 | 0.85 | AURKA (0.49) | DYRK1AIGF1RTGFBR1JAK1TYK2 | |
| SCHEMBL10122960 | 0.72 | AURKA (0.54) | IGF1RSMN1; SMN2TGFBR1LMNAKMT2A | |
| SCHEMBL10123046 | 0.69 | ALDH1A1 (0.49) | SMN1; SMN2TGFBR1LMNAKMT2AALDH1A1 | |
| SCHEMBL10122991 | 0.69 | AURKA (0.49) | IGF1RSMN1; SMN2TGFBR1LMNAKMT2A | |
| SCHEMBL14546516 | 0.68 | ALDH1A1 (0.49) | SMN1; SMN2TGFBR1LMNAKMT2AALDH1A1 | |
| SCHEMBL10123002 | 0.68 | AURKA (0.48) | EPHX2IGF1RLMNAALDH1A1TSHR | |
| SCHEMBL10123026 | 0.66 | AURKA (0.47) | IGF1RSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL10123014 | 0.66 | AURKA (0.49) | IGF1RLMNAALDH1A1GAATYK2 | |
| SCHEMBL10122964 | 0.65 | AURKA (0.50) | IGF1RTGFBR1JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928456-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS INC (US) | 2015-04-22 | — | — | EP | disclosed |