Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | PLEC | Q15149 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | XBP1 | P17861 | 1/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.49 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.49 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420071 | 0.93 | MAPT (0.76) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL13993506 | 0.93 | MAPT (0.61) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123511 | 0.87 | MAPT (0.67) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123545 | 0.86 | MAPT (0.65) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123584 | 0.86 | MAPT (0.65) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123470 | 0.85 | MAPT (0.64) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123543 | 0.82 | MEN1 (0.59) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123506 | 0.82 | EPHX2 (0.67) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL13234045 | 0.81 | NPC1 (0.68) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123512 | 0.81 | ABCC9 (0.60) | MAPTGAATHRBRECQLL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |