Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | PLEC | Q15149 | 1/20 | 0.65 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13993358 | 0.94 | MAPT (0.59) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL420005 | 0.94 | MAPT (0.73) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123511 | 0.86 | MAPT (0.67) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123384 | 0.86 | MAPT (0.67) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123584 | 0.84 | MAPT (0.65) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123470 | 0.84 | MAPT (0.64) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL10123506 | 0.81 | EPHX2 (0.67) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL2704531 | 0.80 | ALDH1A1 (0.58) | MAPTGAATHRBRECQLL3MBTL1 | |
| SCHEMBL15946354 | 0.80 | NPC1 (0.68) | MAPTGAAKDM4ETP53PDK1 | |
| SCHEMBL10123512 | 0.80 | ABCC9 (0.60) | MAPTGAATHRBRECQLL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |