Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393916 | 0.89 | KMT2A (0.49) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL393917 | 0.89 | KMT2A (0.49) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL8312806 | 0.80 | TDP1 (0.42) | KMT2AALDH1A1LMNATDP1SMN1; SMN2 | |
| SCHEMBL12867415 | 0.76 | KMT2A (0.49) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL1170426 | 0.70 | KMT2A (0.45) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL1170425 | 0.70 | KMT2A (0.45) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL1169912 | 0.68 | ALDH1A1 (0.51) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL3596142 | 0.68 | ALDH1A1 (0.54) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL12674503 | 0.64 | KMT2A (0.64) | KMT2AALDH1A1KDM4ELMNAGFER | |
| SCHEMBL397343 | 0.64 | ALDH1A1 (0.51) | KMT2AALDH1A1KDM4ELMNAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088779-A1 | HETEROCYCLIC SULFONAMIDES | CYTOKINETICS, INC. | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088779-A1 | HETEROCYCLIC SULFONAMIDES | TNNI3, TNNT2, MYLK2 | KMT2A 2395/4885ALDH1A1 4297/4885KDM4E 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.