Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123534 | 0.81 | GAA (0.43) | ALDH1A1MAPTCLK1MEN1KMT2A | |
| SCHEMBL10123569 | 0.79 | ALDH1A1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL417881 | 0.76 | PDK1 (0.66) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL7477235 | 0.72 | PDK1 (0.57) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL10123471 | 0.72 | PDK1 (0.63) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL10123574 | 0.71 | GAA (0.40) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL10123572 | 0.71 | KDM4E (0.42) | ALDH1A1MAPTIDO1HTTLMNA | |
| SCHEMBL10123578 | 0.71 | GAA (0.42) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL28378797 | 0.70 | MAPT (0.57) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL13993360 | 0.68 | PDK1 (0.62) | PDK1PDK2PDK3PDK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |