SCHEMBL1012389

SCHEMBL1012389

[CH2]C(C=C)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
DPP4 P27487 2/20 0.41
ALDH1A1 P00352 2/20 0.41
F2 P00734 1/20 0.41
CYP2C19 P33261 1/20 0.40
CYP3A4 P08684 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
ALOX15 P16050 1/20 0.39
HTR2A P28223 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
LMNA P02545 1/20 0.36
CYP2D6 P10635 1/20 0.36
SRC P12931 1/20 0.36
HRH1 P35367 1/20 0.35
MTOR P42345 1/20 0.35
RAB9A P51151 1/20 0.35
GRM7 Q14831 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL109223 0.78 TSHR (0.50) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL19292352 0.77 LMNA (0.48) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL41440 0.77 TSHR (0.41) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL246438 0.77 KDM4E (0.53) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL30724553 0.76 TSHR (0.48) TSHRDPP4ALDH1A1F2CYP2C19
Ammonia Solution, Strong SCHEMBL9691228 0.76 TSHR (0.48) TSHRDPP4ALDH1A1F2CYP2C19
Hydrochloric Acid SCHEMBL11666238 0.76 TSHR (0.48) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL2458793 0.74 DPP4 (0.39) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL4417704 0.74 CYP2D6 (0.46) TSHRDPP4ALDH1A1F2CYP2C19
SCHEMBL28639731 0.74 KDM4E (0.52) TSHRDPP4ALDH1A1F2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 280 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11535751-B2 Asymmetrically substituted polyorganosiloxane derivatives MOMENTIVE PERFORMANCE MATERIALS GMBH 2022-12-27 US claimed
CN-108026279-B Asymmetrically substituted polyorganosiloxane derivatives 莫门蒂夫性能材料有限公司 2022-04-01 CN claimed
CN-108026372-B Modified filler particles and silicone compositions containing the same 莫门蒂夫性能材料有限公司 2022-03-15 CN claimed
US-20180371248-A1 ASYMMETRICALLY SUBSTITUTED POLYORGANOSILOXANE DERIVATIVES CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2018-12-27 US claimed
US-20180208718-A1 MODIFIED FILLER PARTICLES AND SILICONE COMPOSITIONS COMPRISING THE SAME MOMENTIVE PERFORMANCE MATERIALS INC. 2018-07-26 US claimed
EP-3325557-A1 MODIFIED FILLER PARTICLES AND SILICONE COMPOSITIONS COMPRISING THE SAME Momentive Performance Materials GmbH (DE) 2018-05-30 EP claimed
EP-3325540-A1 ASYMMETRICALLY SUBSTITUTED POLYORGANOSILOXANE DERIVATIVES Momentive Performance Materials GmbH (DE) 2018-05-30 EP claimed
CN-108026372-A Modified filler particles and the silicon composition comprising the particle 莫门蒂夫性能材料有限公司 2018-05-11 CN claimed
CN-104558616-B Silicone resin containing aryl and epoxy group, preparation method for silicone resin and epoxy resin adhesive containing silicone resin 郑州中原思蓝德高科股份有限公司 2017-02-22 CN claimed
WO-2017012715-A1 MODIFIED FILLER PARTICLES AND SILICONE COMPOSITIONS COMPRISING THE SAME MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2017-01-26 WO claimed
WO-2017012714-A1 ASYMMETRICALLY SUBSTITUTED POLYORGANOSILOXANE DERIVATIVES MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2017-01-26 WO claimed
CN-104558616-A Silicone resin containing aryl and epoxy group, preparation method for silicone resin and epoxy resin adhesive containing silicone resin ZHENGZHOU ZHONGYUAN APPLIED TECHNOLOGY RES AND DEV CO LTD 2015-04-29 CN claimed
US-12030819-B2 Doped SiC and SiOC compositions and Methods PALLIDUS, INC. (US) 2024-07-09 US disclosed
EP-4392490-A1 IRRADIATION-CURABLE SILICONE COMPOSITION Momentive Performance Materials GmbH (DE) 2024-07-03 EP disclosed
CN-113072072-B Silicon carbide material based on polysilocarb, application and device 帕里杜斯有限公司 2024-07-02 CN disclosed
CN-118176577-A Silicone composition for potting electronic components 迈图高新材料公司 2024-06-11 CN disclosed
CN-86104313-A The preparation method of Imidazoheterocyclic compounds 1987-03-04 CN disclosed
EP-0204285-A1 Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1986-12-10 EP disclosed
EP-0019787-B1 2-PHENYLALKEN-1-YL-CYCLOPROPANE-CARBOXYLIC ACID ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS INSECTICIDES AND ACARICIDES; INTERMEDIATES IN THEIR PREPARATION BAYER AG (DE) 1984-03-14 EP disclosed
EP-0019787-A2 2-Phenylalken-1-yl-cyclopropane-carboxylic acid esters, process for their preparation and their use as insecticides and acaricides; intermediates in their preparation BAYER AG (DE) 1980-12-10 EP disclosed