SCHEMBL10124154

SCHEMBL10124154

CC(=O)c1cc(C)c(NC(=O)c2cc(Cn3nnc(C(F)(F)F)n3)nn2-c2ncccc2Cl)c(C(=O)NC2CC2)c1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 13/20 0.37
MAPK14 Q16539 2/20 0.37
MAPK13 O15264 1/20 0.37
MAPK12 P53778 1/20 0.37
MAPK11 Q15759 1/20 0.37
CRHR2 Q13324 1/20 0.35
PDE4B Q07343 2/20 0.34
GRM4 Q14833 1/20 0.34
NTRK1 P04629 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10124181 0.94 CRHR1 (0.37) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL13085179 0.93 CRHR1 (0.38) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL685487 0.93 CRHR1 (0.38) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL13084993 0.92 CRHR1 (0.38) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL13084961 0.92 CRHR1 (0.38) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL13085104 0.92 CRHR1 (0.38) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL10124152 0.91 DHODH (0.32)
SCHEMBL10075531 0.90 CRHR1 (0.37) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL13085091 0.90 CRHR1 (0.36) CRHR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL13085060 0.90 CRHR1 (0.36) CRHR1MAPK14MAPK13MAPK12MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9790202-B2 Anthranilamide derivatives as pesticides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-10-17 US disclosed
US-9790202-B2 Anthranilamide derivatives as pesticides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-10-17 US disclosed
US-20120010250-A1 Anthranilamide derivatives as pesticides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20120010250-A1 Anthranilamide derivatives as pesticides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010250-A1 Anthranilamide derivatives as pesticides ANTXR2, NQO2, AADAC CRHR1 3796/4885MAPK14 3140/4885MAPK13 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.