Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015276 | 0.99 | SERPINE1 (0.65) | SERPINE1MITFKLF5POLBG6PD | |
| SCHEMBL1012593 | 0.89 | SERPINE1 (0.52) | SERPINE1MITFKLF5ALDH1A1HPGD | |
| SCHEMBL1013722 | 0.89 | SERPINE1 (0.52) | SERPINE1MITFKLF5KDM4EHSD17B10 | |
| SCHEMBL1015307 | 0.88 | SERPINE1 (0.64) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1015323 | 0.87 | SERPINE1 (0.65) | SERPINE1MITFKLF5KDM4EHSD17B10 | |
| SCHEMBL419999 | 0.85 | SERPINE1 (0.66) | SERPINE1POLBG6PDALDH1A1KCNJ6 | |
| SCHEMBL1797569 | 0.84 | SERPINE1 (0.56) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1015522 | 0.82 | RAB9A (0.55) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1013771 | 0.80 | SERPINE1 (0.49) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1015397 | 0.79 | SERPINE1 (0.50) | SERPINE1POLBG6PDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |