Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015397 | 0.99 | SERPINE1 (0.50) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1013772 | 0.90 | KMT2A (0.44) | SERPINE1POLBG6PDKDM4EMEN1 | |
| SCHEMBL1013555 | 0.89 | KMT2A (0.48) | POLBKDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL1015239 | 0.87 | SERPINE1 (0.50) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1014856 | 0.86 | SERPINE1 (0.51) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1015522 | 0.83 | RAB9A (0.55) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1012592 | 0.80 | SERPINE1 (0.64) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1015240 | 0.80 | MEN1 (0.46) | SERPINE1POLBG6PDKDM4EMEN1 | |
| SCHEMBL1015276 | 0.79 | SERPINE1 (0.65) | SERPINE1POLBG6PDKDM4EHSD17B10 | |
| SCHEMBL1797141 | 0.78 | SERPINE1 (0.55) | SERPINE1POLBG6PDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |