Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501994 | 0.81 | KDM4E (0.77) | ALDH1A1KDM4ESMN1; SMN2ENPP1EGFR | |
| SCHEMBL1010778 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KDM4ESMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL31352747 | 0.78 | ALDH1A1 (0.81) | ALDH1A1KDM4ESMN1; SMN2TNFENPP1 | |
| SCHEMBL2119205 | 0.77 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2KDR | |
| SCHEMBL27349599 | 0.75 | KDM4E (0.65) | ALDH1A1KDM4ESMN1; SMN2EHMT2ENPP1 | |
| SCHEMBL1012226 | 0.75 | ENPP1 (0.68) | ENPP1KDR | |
| SCHEMBL4373124 | 0.75 | ENPP1 (0.68) | ENPP1KDR | |
| SCHEMBL27607881 | 0.73 | KDM4E (0.58) | ALDH1A1KDM4ESMN1; SMN2EHMT2EHMT1 | |
| SCHEMBL6030063 | 0.72 | SMN1; SMN2 (0.68) | ALDH1A1KDM4ESMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL27352432 | 0.72 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2ENPP1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |