Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 8/20 | 0.42 |
| ▸ | FLT1 | P17948 | 6/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2119205 | 0.95 | ALDH1A1 (0.68) | KDM4EALDH1A1SMN1; SMN2PDPK1KDR | |
| SCHEMBL1010778 | 0.87 | ALDH1A1 (1.00) | KDM4EALDH1A1SMN1; SMN2PDPK1PDGFRB | |
| SCHEMBL31352747 | 0.85 | ALDH1A1 (0.81) | KDM4EALDH1A1SMN1; SMN2SRCENPP1 | |
| SCHEMBL29597309 | 0.84 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2PDPK1KDR | |
| SCHEMBL27349599 | 0.81 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2ENPP1EGFR | |
| SCHEMBL1012610 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1SMN1; SMN2KDRENPP1 | |
| SCHEMBL21676219 | 0.80 | PGK1 (0.51) | KDM4EALDH1A1SMN1; SMN2PDPK1KDR | |
| SCHEMBL6030063 | 0.78 | SMN1; SMN2 (0.68) | KDM4EALDH1A1SMN1; SMN2PDPK1PDGFRB | |
| SCHEMBL30177543 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2PDPK1KDR | |
| SCHEMBL27352432 | 0.78 | ALDH1A1 (0.69) | KDM4EALDH1A1SMN1; SMN2PDPK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |