Sugi Predict

Sugi Predict / Compounds / SCHEMBL10127280

SCHEMBL10127280

SCHEMBL10127280

CC1=Nc2c(cc(-c3cc(C(=O)NCCS(=O)(=O)O)nc(C(=O)NCCS(=O)(=O)O)c3)c3ccccc23)C1(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 1/20 0.35
▸ HPGD P15428 2/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ MITF O75030 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ RAD52 P43351 1/20 0.33
▸ HDAC3 O15379 4/20 0.33
▸ HDAC4 P56524 4/20 0.33
▸ HDAC1 Q13547 4/20 0.33
▸ HDAC7 Q8WUI4 4/20 0.33
▸ HDAC2 Q92769 4/20 0.33
▸ HDAC10 Q969S8 4/20 0.33
▸ HDAC11 Q96DB2 4/20 0.33
▸ HDAC8 Q9BY41 4/20 0.33
▸ HDAC6 Q9UBN7 4/20 0.33
▸ HDAC9 Q9UKV0 4/20 0.33
▸ HDAC5 Q9UQL6 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10127146 0.95 KDM4C (0.37) HTTHPGDMEN1KMT2AMAPK1
SCHEMBL15401282 0.86 ULK1 (0.30) —
SCHEMBL178267 0.80 TLR7 (0.35) HPGDMEN1KMT2AMAPK1HDAC3
SCHEMBL178262 0.79 CNR1 (0.34) HPGDMEN1KMT2AMITFPOLB
SCHEMBL16252091 0.78 HTT (0.34) HTTHPGDMEN1KMT2AMAPK1
SCHEMBL15401279 0.77 — —
SCHEMBL15522207 0.76 — —
SCHEMBL16252103 0.74 HTT (0.33) HTTHPGDMEN1KMT2AMAPK1
SCHEMBL178241 0.74 ULK1 (0.31) —
SCHEMBL178268 0.73 MEN1 (0.40) HPGDMEN1KMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11624089-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2023-04-11 — — US disclosed
US-20200232023-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2020-07-23 — — US disclosed
US-10392659-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2019-08-27 — — US disclosed
US-20170183501-A1 Cyanine Dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2017-06-29 — — US disclosed
US-9441270-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2016-09-13 — — US disclosed
US-20150072894-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2015-03-12 — — US disclosed
US-8889886-B2 Cyanine dyes PACIFIC BIOSCIENCES, INC. (US) 2014-11-18 — — US disclosed
US-20120052506-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — US disclosed
WO-2012027623-A2 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10392659-B2 Cyanine dyes ABCG2, IK, ACR HTT 1241/4885HPGD 4047/4885MEN1 2288/4885
US-11624089-B2 Cyanine dyes ABCG2, IK, ACR HTT 1241/4885HPGD 4047/4885MEN1 2288/4885
US-20120052506-A1 CYANINE DYES ABCG2, IK, ACR HTT 1241/4885HPGD 4047/4885MEN1 2288/4885
US-20200232023-A1 CYANINE DYES ABCG2, IK, ACR HTT 1241/4885HPGD 4047/4885MEN1 2288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.