Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27644903 | 0.86 | MTNR1A (0.49) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL27662593 | 0.86 | MTNR1A (0.54) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL9835557 | 0.85 | MTNR1A (0.48) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL9615375 | 0.85 | MTNR1A (0.51) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL20264517 | 0.81 | HSD17B2 (0.61) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1779795 | 0.80 | MTNR1A (0.44) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL16969130 | 0.80 | PTGIR (0.47) | MTNR1AMTNR1BHSD17B2HSD17B1NPC1 | |
| SCHEMBL4293536 | 0.79 | MTNR1A (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL27839545 | 0.79 | MTNR1A (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1703740 | 0.79 | MTNR1A (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |