Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20264517 | 0.81 | HSD17B2 (0.61) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1007582 | 0.80 | MTNR1A (0.44) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL4293536 | 0.79 | MTNR1A (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1012749 | 0.79 | MTNR1A (0.51) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL27839545 | 0.79 | MTNR1A (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL17501940 | 0.77 | MTNR1A (0.49) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1704086 | 0.77 | RAB9A (0.49) | HSD17B2HSD17B1LMNAPOLBPARP1 | |
| SCHEMBL4789340 | 0.76 | MTNR1A (0.47) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL26624252 | 0.75 | MTNR1B (0.56) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL7985806 | 0.75 | MEN1 (0.65) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558069-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-2512478-A1 | HOMOGENEOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF | Novartis AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| EP-2440245-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | Novartis AG (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011130379-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011084549-A1 | HOMOGENEOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2011-07-14 | — | — | WO | disclosed |
| CN-102015651-A | Compounds and compositions as TLR activity modulators | IRM LLC | 2011-04-13 | — | — | CN | disclosed |
| WO-2010144734-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | NOVARTIS AG (CH) | 2010-12-16 | — | — | WO | disclosed |