Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PDE6D | O43924 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915393 | 0.91 | HMGCR (0.48) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129521 | 0.88 | HMGCR (0.48) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL699219 | 0.88 | HMGCR (0.65) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL699218 | 0.88 | HMGCR (0.65) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129222 | 0.85 | HMGCR (0.48) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129259 | 0.82 | HMGCR (0.48) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129258 | 0.81 | HMGCR (0.47) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129522 | 0.81 | GCGR (0.57) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL10129526 | 0.77 | HMGCR (0.46) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL26305518 | 0.77 | HMGCR (0.65) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423195-A1 | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof | LEK Pharmaceuticals d.d. (SI) | 2012-02-29 | — | — | EP | disclosed |
| WO-2012013325-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS D.D. (SI) | 2012-02-02 | — | — | WO | disclosed |