Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778851 | 1.00 | ALDH1A1 (0.54) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL3192684 | 0.82 | ALDH1A1 (0.62) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL18299305 | 0.80 | GRIN2D (0.41) | ALDH1A1TDP1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL4427648 | 0.79 | ALDH1A1 (0.71) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL2946228 | 0.77 | TSHR (0.59) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL30313551 | 0.77 | TSHR (0.59) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL19690422 | 0.75 | ALDH1A1 (0.54) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL1199723 | 0.75 | ALDH1A1 (0.54) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL5206322 | 0.75 | ALDH1A1 (0.54) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL31282358 | 0.75 | ALDH1A1 (0.54) | ALDH1A1TDP1TSHRCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313231-B | OGA inhibitor compounds | 詹森药业有限公司 | 2023-05-09 | — | — | CN | disclosed |
| EP-3810608-B1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2022-08-10 | — | — | EP | disclosed |
| CN-112313231-A | OGA inhibitor compounds | 詹森药业有限公司 | 2021-02-02 | — | — | CN | disclosed |
| EP-3083554-B1 | DIMETHYLBENZOIC ACID COMPOUNDS | LILLY CO ELI (US) | 2019-03-13 | — | — | EP | disclosed |
| US-10005721-B2 | Dimethylbenzoic acid compounds | ELI LILLY AND COMPANY (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005721-B2 | Dimethylbenzoic acid compounds | ELI LILLY AND COMPANY (US) | 2018-06-26 | — | — | US | disclosed |
| EP-2867218-B1 | Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions | LILLY CO ELI (US) | 2017-02-22 | — | — | EP | disclosed |
| EP-2867218-B1 | Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions | LILLY CO ELI (US) | 2017-02-22 | — | — | EP | disclosed |
| EP-3083554-A1 | DIMETHYLBENZOIC ACID COMPOUNDS | Eli Lilly & Company (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160251306-A1 | DIMETHYLBENZOIC ACID COMPOUNDS | ELI LILLY AND COMPANY | 2016-09-01 | — | — | US | disclosed |
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | disclosed |
| US-20100029657-A1 | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof | WYETH (US) | 2010-02-04 | — | — | US | disclosed |
| CN-101578259-A | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators | VALEANT PHARMACEUTICALS INT (US) | 2009-11-11 | — | — | CN | disclosed |
| WO-2009108838-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |
| EP-2086925-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | Valeant Pharmaceuticals International (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20080234334-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234334-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234334-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-09-25 | — | — | US | disclosed |
| WO-2008066900-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008066900-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234334-A1 | 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS | KCNB2, KCNB1, KCNA1 | ALDH1A1 1031/4885TDP1 1051/4885TSHR 3206/4885 |
| US-20100029657-A1 | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof | BRAF, RAF1, ARAF | ALDH1A1 1029/4885TDP1 1494/4885TSHR 2494/4885 |
| US-10005721-B2 | Dimethylbenzoic acid compounds | PTGER4, EDNRB, EPB41 | ALDH1A1 272/4885TDP1 4081/4885TSHR 524/4885 |
| US-20160251306-A1 | DIMETHYLBENZOIC ACID COMPOUNDS | PTGER4, EDNRB, EPB41 | ALDH1A1 272/4885TDP1 4081/4885TSHR 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.