⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406175 | 1.00 | — | — | |
| SCHEMBL28350812 | 0.85 | HCAR2 (0.44) | — | |
| SCHEMBL29084262 | 0.84 | NFE2L2 (0.43) | — | |
| SCHEMBL28045540 | 0.83 | MAPT (0.56) | — | |
| SCHEMBL21126429 | 0.81 | TDP1 (0.46) | — | |
| SCHEMBL14790719 | 0.78 | NFE2L2 (0.52) | — | |
| SCHEMBL15962307 | 0.77 | — | — | |
| SCHEMBL17528621 | 0.77 | NFE2L2 (0.50) | — | |
| Dimethyl Fumarate SCHEMBL41836 | 0.76 | NFE2L2 (1.00) | — | |
| Dimethyl Maleate SCHEMBL75864 | 0.76 | NFE2L2 (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118515614-A | Synthesis method of difluoro pyrazole acid | 南京大学 | 2024-08-20 | — | — | CN | claimed |
| CN-117850088-A | Ultrathin flexible polarizing cover plate, preparation method thereof and touch display device | 深圳市鑫晶科光电设备有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-115193419-B | Magnetic microsphere, preparation method, application and diagnostic kit thereof | 苏州纳微生命科技有限公司 | 2022-11-22 | — | — | CN | claimed |
| CN-115193419-A | Magnetic microsphere, preparation method, application and diagnostic kit thereof | 苏州纳微生命科技有限公司 | 2022-10-18 | — | — | CN | claimed |
| EP-2195284-B1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2017-03-22 | — | — | EP | claimed |
| EP-2245001-B1 | Method for the production of 2-fluoroacyl-3-amino-acrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-03-20 | — | — | EP | claimed |
| US-8288582-B2 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-10-16 | — | — | US | claimed |
| US-8258335-B2 | Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-09-04 | — | — | US | claimed |
| EP-1458670-B1 | METHOD FOR PRODUCING 2-HALOGENACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | SALTIGO GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| EP-2245001-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-11-03 | — | — | EP | claimed |
| US-20100204483-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-08-12 | — | — | US | claimed |
| EP-2195284-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-06-16 | — | — | EP | claimed |
| WO-2009083134-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-07-09 | — | — | WO | claimed |
| EP-2072497-A1 | Method for manufacturing 2-fluoracyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-06-24 | — | — | EP | claimed |
| WO-2009043444-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-04-09 | — | — | WO | claimed |
| EP-2042482-A1 | Method for manufacturing 2-dihalogenacyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-04-01 | — | — | EP | claimed |
| US-6706911-B1 | REACTING N-SUBSTITUTED 3-AMINOACRYLIC ESTERS WITH HALOALKYLCARBOXYLIC ANHYDRIDES IN PRESENCE OF BASE; PYRAZOLE-4-CARBOXYLIC ACID CHEMICAL INTERMEDIATES; HALOACYLATION | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-16 | — | — | US | claimed |
| EP-0176846-B1 | 3-AMINO-2-BENZOYL-ACRYLIC-ACID DERIVATIVES AND PROCESS FOR THEIR PREPARATION | BAYER AG (DE) | 1989-08-16 | — | — | EP | claimed |
| CN-85101686-B | 3-amino-2-benzoyl-acrylic acid derivative and a process for producing the same | 拜尔公司 | 1988-12-14 | — | — | CN | claimed |
| EP-0176846-A2 | 3-Amino-2-benzoyl-acrylic-acid derivatives and process for their preparation | BAYER AG (DE) | 1986-04-09 | — | — | EP | claimed |