Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Maleate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 1.00 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 1.00 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Fumarate SCHEMBL41836 | 1.00 | NFE2L2 (1.00) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL41835 | 1.00 | NFE2L2 (1.00) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL11668350 | 1.00 | NFE2L2 (1.00) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Maleate SCHEMBL28991725 | 0.96 | NFE2L2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Maleate SCHEMBL20854972 | 0.96 | NFE2L2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Maleate SCHEMBL6505431 | 0.96 | NFE2L2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Maleate SCHEMBL7057632 | 0.96 | HCAR2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL21219085 | 0.96 | NFE2L2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL29395244 | 0.96 | NFE2L2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| Dimethyl Maleate SCHEMBL7057629 | 0.96 | NFE2L2 (0.93) | NFE2L2HCAR2KEAP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33294 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114868298-B | Composite stripping method | Guangdong Haozhi Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-117264159-B | Preparation method and application of anionic water-based polyaspartic acid ester resin | ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2026-05-26 | — | — | CN | claimed |
| EP-4745214-A1 | PROCESS FOR THE TREATMENT OF A PYROLYSIS OIL | Repsol, S.A. (ES) | 2026-05-20 | — | — | EP | claimed |
| EP-4067466-B1 | WASHING OR CLEANING AGENT | HENKEL AG & CO KGAA (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-122060453-A | Addition type solidified organic silicon conductive silver adhesive and preparation method thereof | 浙江新安化工集团股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122070479-A | Ultrasonic indicating device and method for monitoring ultrasonic treatment | JP实验室股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122060128-A | Polycarboxylic acid water reducer based on photoinitiated polymerization, and preparation method and application thereof | 安徽海螺材料科技股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-12629669-B2 | Method for rejuvenating a catalyst from a hydroprocessing and/or hydrocracking process | IFP Energies Nouvelles (FR) | 2026-05-19 | — | — | US | claimed |
| CN-122036783-A | Organosilicon modified polyaspartic acid ester polyurea and preparation method thereof | 深圳市宝安区新材料研究院 | 2026-05-15 | — | — | CN | claimed |
| CN-122030386-A | Pesticide synergistic auxiliary agent and preparation method thereof | 青岛恒宁生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-3990980-A | Hybrid liquid toners | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |
| US-3991226-A | Method of creating an image using hybrid liquid toners | PHILIP A. HUNT CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | claimed |
| US-3989767-A | Powder coating resin compositions of glycidyl copolymers having an internal flowing agent | DAINIPPON INK & CHEMICALS, INCORPORATED (JA) | 1976-11-02 | — | — | US | claimed |
| US-3971746-A | Synthetic polyisoprene rubber latex | KURARAY CO., LTD. (JA) | 1976-07-27 | — | — | US | claimed |
| US-3969433-A | ADDITION POLYMER | KOSE AKIRA | 1976-07-13 | — | — | US | claimed |
| US-3959189-A | Process for producing polyethylene resin particles and foamable polyethylene resin particles | Sekisui Kaseihin Kabushiki Kaisha (JA) | 1976-05-25 | — | — | US | claimed |
| US-3957732-A | ALTERNATING COPOLYMERS HAVING FUNCTIONAL GROUP AND PROCESS FOR PRODUCING SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-05-18 | — | — | US | claimed |
| US-3952023-A | Method for preparing adduct of butadiene polymer or copolymer and α, β-ethylenically unsaturated dicarboxylic acid compound | NIPPON OIL COMPANY LTD. (JA) | 1976-04-20 | — | — | US | claimed |
| US-3951925-A | TWO STEP SUSPENSION POLYMERIZATION USING AN OIL SOLUBLE RADICAL INITIATOR | CHISSO CORPORATION (JA) | 1976-04-20 | — | — | US | claimed |
| US-3941912-A | Copolymer latex and paper coating composition thereof | SUMITOMO NAUGATUCK CO., LTD. (JA) | 1976-03-02 | — | — | US | claimed |