Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303856 | 0.81 | PDGFRA (0.47) | PDGFRACDK5TYRO3ELANEMAP3K14 | |
| SCHEMBL10112235 | 0.81 | PDGFRA (0.70) | PDGFRACDK5TYRO3ELANEMAP3K14 | |
| SCHEMBL726679 | 0.76 | ELANE (0.60) | ELANEIKBKEIKBKBNR1H2NR1H3 | |
| SCHEMBL14186868 | 0.74 | ADORA2A (0.59) | KMO | |
| SCHEMBL733143 | 0.71 | PDGFRA (0.57) | PDGFRACDK5TYRO3ELANEMAP3K14 | |
| SCHEMBL13516579 | 0.70 | TDP1 (0.46) | ELANEMAP3K14SLC22A12ALDH1A1HSD17B10 | |
| SCHEMBL176951 | 0.69 | ELANE (0.42) | ELANEKMOSLC22A12TAAR1 | |
| SCHEMBL3699843 | 0.68 | ELANE (0.41) | PDGFRACDK5TYRO3ELANEMAP3K14 | |
| SCHEMBL17514107 | 0.68 | ELANE (0.41) | ELANEKMOSLC22A12ALDH1A1HSD17B10 | |
| SCHEMBL28311685 | 0.68 | SLC22A12 (0.56) | ELANEKMOSLC22A12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, ADAMTS1, ADAMTS7 | PDGFRA 2031/4885CDK5 1032/4885TYRO3 3665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.